Making the Cut with CRISPR-Cas9©
Your students have heard about CRISPR, now, they can model how this protein can modify DNA. With Making the Cut with CRISPR-Cas9©’s colorful foam pieces and placemat your students can build an interactive model of the CRISPR-Cas9 RNA-guided endonuclease, including the viral double-stranded DNA and dual guide RNA. You can observe students transferring their prior knowledge of DNA structure while modeling how the Cas9 protein functions.
- Build a schematic model of the CRISPR-Cas9 RNA-guided endonuclease, including the viral double-stranded DNA and dual guide RNA
- Understand how the Cas9 protein binds to a specific sequence of viral double-stranded DNA at a PAM site – and cuts it
- Demonstrate how that cut destroys the viral genome and prevents the infection of bacteria
- Amplify their learning with student handouts and digital materials
You can observe students transferring their prior knowledge of DNA structure while modeling how the Cas9 protein functions.
Learn more about Making the Cut with CRISPR-Cas9©
Student Handouts
Other Resources
Genome Editing Webinar PowerPoint presentation
Genome Editing Webinar PDF of PowerPoint presentation
May 2016 Nature article: “Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage”
October 2018 Nature Methods article: “Base editing a CRISPR way”
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