De Novo Proteins
This model of a de novo protein from the University of Washington’s Institute for Protein Design communicates the overall repeating shape of a tightly packed beta barrel. Embedded magnets allow each of the four monomers to separate and select sidechains (white) show the tight interaction between the monomers.
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De Novo Proteins
This model of a de novo protein from the University of Washington’s Institute for Protein Design communicates the overall repeating shape of an alpha helix spiral. Each protein repeat is colored uniquely (rainbow gradient) and shown in a ribbon display format. Embedded magnets allow the individual repeats to disassemble.
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De Novo Proteins
This model collection of de novo proteins was made in collaboration with the University of Washington’s Institute for Protein Design and was featured in the New York Times. It demonstrates the wide variety of shapes and functions being explored by the IPD and how physical models can communicate complex protein research to general audiences.
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De Novo Proteins
This model of a de novo protein from the University of Washington’s Institute for Protein Design communicates the icosahedral nature of the structure. Over 120 individual green fluorescent proteins (green) were attached to sixty protein chains (blue) to create the spherical structure.
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De Novo Proteins
This model of a de novo protein from the University of Washington’s Institute for Protein Design communicates the complementary surface of two small peptide strands. The model is shown in wireframe display format (colored by element) with a transparent shell representing the solvent accessible molecular surface. Embedded magnets allow the transparent shell to pull apart and the small peptide strands to be removed.
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De Novo Proteins
This model of a de novo protein from the University of Washington’s Institute for Protein Design communicates the overall beta barrel shape of the structure. The protein (white, blue and red) includes embedded magnets that allow it to attach to a unique human-hand display base (silver and black). The small molecule (green) that binds to the protein also includes an LED that lights up when the molecule is properly docked into the protein.
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De Novo Proteins
This collection of de novo protein models was designed in collaboration with the University of Washington’s Institute for Protein Design and shows the same protein structure in a variety of different display formats. A small molecule (magenta) has embedded magnets that allow it to separate from the protein structures.
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De Novo Proteins
This collection of de novo protein models was design in collaboration with the University of Washington’s Institute for Protein Design and shows the overall structure of a structural protein. Each monomer (light and dark blue) includes embedded magnets that allow them to be stacked together into the full cylindrical structure.
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