Receptors
This G-protein coupled receptor model communicates the overall domains and orientation of an important class of receptor proteins. Designed to complement a special issue of Nature, the G-proteins are shown in surface display format and colored red, yellow and green. The receptor is shown in surface display format and colored by electrostatic potential (blue to red). The model uses embedded magnets to disassemble and attach to the display base.
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Receptors
This dopamine receptor model communicates the overall structure of dopamine receptors along with three potential drugs that bind to the receptor. Embedded magnets allow the small molecule drugs (colored by element) to each attach in the binding site of the dopamine receptor (colored by rainbow gradient).
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Receptors
This TAK1 protein model communicates the overall structure of the active site and how three competing small molecules bind. The TAK1 protein (white) is shown in ribbon display format and the small molecule drugs (colored by element) are shown in ball-and-stick display format. Embedded magnets allow each small molecule to be attached in the protein active site.
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Receptors
This KRAS protein model communicates the overall structure of the enzyme and how a substrate fits into the active site. The protein (white and green) is fit with embedded magnets that allow the substrate (cyan) and the display base to be detached. Select sidechains are also shown (colored by element) to highlight specific binding chemistry.
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Receptors
This Endoglycosidase enzyme model communicates the overall binding surface of the protein and how several similar small molecules compete for the binding site. The protein (colored by electrostatic potential) is shown in surface display format and the small molecule substrates (green) are shown in ball-and-stick display format. Embedded magnets allow each substrate to dock into the enzyme active site.
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Receptors
This protein kinase model communicates the overall structure of the protein binding site and how the small molecule MEK inhibitor binds to the protein. The kinase protein (blue) is shown in cartoon display format and the small molecule inhibitor (colored by element) is shown in ball-and-stick format. Embedded magnets allow for the inhibitor to removed from the protein for a better view of the active site.
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This collection of hepatitis HCV protein models communicate the overall shape of the virus structural protein and how small molecule inhibitors bind to and disrupt the virus. The proteins (green, red, blue and yellow/orange) are shown in surface display format and the small molecule inhibitors (colored by element) are shown in ball-and-stick format. Embedded magnets allow the small molecule inhibitors to be removed from the protein surfaces.
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