ß-Globin Folding Kit©

Lending Library

One kit is all you need to engage three teams of up to 6 students each in collaboration about the molecular cause of sickle cell anemia.

Loan Period


Loan Time Frame: 3 weeks (1 week loan plus 2 weeks for delivery and return shipping)

Local Pickup (Greater Milwaukee Area)

Loan Time Frame: 2 weeks


You only pay for return shipping
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Teaching Points

Reveal the molecular relationship between structure and function, protein synthesis, and mutation as you tell classic stories in biology. Oxygen transport and how it can be disrupted becomes real in your students’ hands as they:

  • Interpret folding maps to form the primary structure of the protein with mini toobers
  • Fold 3 mini toobers into alpha helices and then their tertiary structures
  • Assemble the three fragments together to form ß-globin
  • Add the heme group with an iron atom and O2

You can create an authentic application activity as students predict the impact of a single-point mutation on the function of the protein. This kit is most effective after students have explored the Amino Acid Starter Kit©.

Find additional resources for this kit here: ß-Globin Folding Kit© Classroom Resources

Included Materials

2 ß-Globin Folding Kits© per case – Each kit includes:

  • 3 Mini Toobers (red, green, and blue)
  • 3 Laminated Folding Maps
  • 4 Bags with Parts (blue, green, red, and yellow)
  • Amino Acid Side Chains
  • Heme Group and Heme Connectors
  • Plastic Clips
  • Markers
  • Support Posts
  • Colored Dots
  • 3 Laminated Amino Acid Side Chain Charts©
  • 3 Wooden Dowels