Substrate Specificity Kit©

Lending Library

Puzzling promotes sensemaking when students engineer an enzyme’s active site.

Loan Period

Delivery

Loan Time Frame: 3 weeks (1 week loan plus 2 weeks for delivery and return shipping)

Local Pickup (Greater Milwaukee Area)

Loan Time Frame: 2 weeks

Cost

You only pay for return shipping
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Teaching Points

Your students can model the highly specific interaction between a substrate and an enzyme. Students can:

  • Build a substrate and identify its chemical properties
  • Fold a mini toober to create an active site for that substrate
  • Discover subtle changes in enzyme structure that can impact substrate binding

You can even explore the various types of specificity, including stereochemical specificity and absolute specificity.

Find additional resources for this kit here: Substrate Specificity Kit© Classroom Resources

Included Materials

  • 6 Substrate Specificity Kits© per case – Each contains:
    • 1 3-foot mini toober
    • 1 6-foot mini toober
    • 1 blue functional group
    • 1 red functional group
    • 1 white functional group
    • 2 yellow functional groups
    • 1 4-hole sphere
    • 1 2-hole sphere and post
    • 5 metal clips
    • 1 sheet of colored clip labels
    • 2 sets of red and blue endcaps
    • 1 Amino Acid Side Chain Chart
  • 6 Enzymes in Action Kits© per case – Each contains:
    • 10 Foam Pieces
    • 2 Enzymes
    • 2 Catabolism Substrates
    • 2 Anabolism Substrates
    • 1 Specificity Substrate
    • 1 Incompatible Substrate
    • 1 Competitive Inhibitor
    • 1 Noncompetitive Inhibitor
    • 1 Sticker Sheet
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